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By blocking the enzyme in the wall of the stomach that produces acid. Nexium decreases the amount of acid backing up into the esophagus and causing reflux symptoms. Esomeprazole works best if taken on an empty stomach at least one hour before a meal. Nexium capsules should be taken at least one hour before meals, swallowed whole and shouldn't be crushed or chewed. Nexium is usually taken once a day at least one hour before a meal. Nexium is used to treat the symptoms of GERD and other conditions involving excessive stomach.
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