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There is an increased risk of breast cancer. Menopause are more likely to develop gallbladder disease. Premarin is also controversial because the health risks to women of absorbing a substance made from equine waste may not be fully known. This medication may actually increase your risk of developing endometrial hyperplasia, a condition that may lead to cancer of the uterus. Because this medication may interfere with some laboratory tests. Women with ovarian failure or other conditions that cause a lack of natural estrogen in the body. Women taking estrogens.