Fluconazole increases the concentration of Celecoxib in the liver. Celebrex works by blocking the action of a substance in the body by inhibiting the breakdown of Celecoxib in the liver. Celebrex works by blocking the action of a substance in the body called cyclo-oxygenase. Celecoxib does not interfere with the clotting of blood. Before taking Celecoxib, tell your doctor or pharmacist if you are allergic to it or to sulfa drugs. Celebrex is used to treat arthritis, acute pain, and menstrual pain and discomfort.
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