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Keflex may not be well tolerated by all patients and a thorough medical history is recommended prior to prescribing this medication. Cephalexin may be given on an empty stomach or with food to prevent stomach upset. Keflex may not be well tolerated by all patients and a thorough medical history is recommended prior to prescribing this medication. The amount of medicine in your body is kept at a constant level. Cephalexin is a broad-spectrum antibiotic used to treat certain infections caused by susceptible bacteria sinusitis, respiratory infections, otitis media, skin and soft tissue infections, bone infections, acute prostatitis and some dental infections. Keflex is effective antibiotic therapy for skin and skin structure infections and is the most prescribed oral cephalosporin medicine. It contains sugar which can affect a diabetic. The growth of micro-organisms such as bacteria, fungi, or protozoa. Patients and a thorough medical history is recommended prior to prescribing this medication.